Nonstochastic effects of different energy. beta. emitters on the mouse skin

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576376· OSTI ID:6628802

Coggle, J E; Hansen, L S; Wells, J; Charles, M W

The effect of irradiating varying areas of mouse skin from 860 down to 0.8 mm/sup 2/ with different energy ..beta.. emitters was studied to clarify protection problems of localized doses to the skin. Both /sup 90/Sr and /sup 170/Tm sources show area effects for dose-response curves. The /sup 90/Sr doses that produced moist desquamation in 50% of irradiated fields (MD-50 doses) were 22, 42, 70, and 1000 Gy for 400-, 95-, 20-, and 0.8-mm/sup 2/ sources. The MD-50 doses for /sup 170/Tm were 50, 54, 90, and 170 Gy for 860-, 64-, 20-, and 3.1-mm/sup 2/ sources. Thus for the larger /sup 170/Tm sources there is much less area effect. There was no significant difference in effect between the different energy /sup 90/Sr and /sup 170/Tm sources for moist desquamation. The doses needed for 50% of the mice to show ulceration after 64-, 20-, and 3.1-mm/sup 2/ /sup 170/Tm sources were 260, 550, and 8300 Gy, respectively, while those for 90-, 20-, and 0.8-mm/sup 2/ /sup 90/Sm sources were 150, 210, and 3100 Gy. Thus there is a definite area and energy effect for these sources for this deep dermal damage.

• Research Organization: St. Bartholomew's Hospital, London, England
• OSTI ID: 6628802
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DECAY
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHEMA
EVEN-EVEN NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RODENTS
SKIN
STRONTIUM 90
STRONTIUM ISOTOPES
SURFACE AREA
SURFACE PROPERTIES
SYMPTOMS
THULIUM 170
THULIUM ISOTOPES
ULCERS
VERTEBRATES
YEARS LIVING RADIOISOTOPES