Phase I and II trial of five-day infused 5-fluorouracil and radiation in advanced cancer of the head and neck
Journal Article
·
· J. Clin. Oncol.; (United States)
OSTI ID:6627003
Eighteen patients with advanced epithelial cancers of the head and neck region were studied for their tolerance and response to combined cycles of 120-hour infused 5-fluorouracil (5-FU) and external-beam radiation therapy. 5-FU infusions were given under conditions where radiosensitization would be expected at the higher infusion doses. Coincident radiation treatments were given as four sequential daily fractions of 250 rad each administered during days 1 through 4 of each five-day infusion cycle. The patients were rested for at least nine days after each cycle or longer until toxicity was resolved. The regimen was then repeated in each patient for a total of five treatment cycles. Thereafter therapy was consolidated, usually by boost radiation without drug. In sequential patient subsets the infusion load was progressively escalated in a phase I format. The complete response rate for stage IV patients was 75% with survival benefit compared to prior results. 5-FU dose-dependent combined modality loco-regional toxicity was demonstrated without significant enhancement of systemic toxicity of any form; 5-FU dose-dependent enhanced responsiveness and survival benefit is also suggested. Further scheduling and response studies of 5-FU under radiosensitizing conditions appear warranted.
- Research Organization:
- Division of Radiation Oncology, University of California Medical School, San Diego
- OSTI ID:
- 6627003
- Journal Information:
- J. Clin. Oncol.; (United States), Journal Name: J. Clin. Oncol.; (United States) Vol. 2:5; ISSN JCOND
- Country of Publication:
- United States
- Language:
- English
Similar Records
Phase I and pharmacologic study of 72-hour infused 5-fluorouracil and hyperfractionated cyclical radiation
Pilot study of combination 5-fluorouracil, cisdiamminedichloroplatinum II, and radiation therapy for grade III and IV astrocytomas
Hepatic Arterial Infusion Chemotherapy Using Fluorouracil Followed by Systemic Therapy Using Oxaliplatin Plus Fluorouracil and Leucovorin for Patients with Unresectable Liver Metastases from Colorectal Cancer
Journal Article
·
Sun Mar 31 23:00:00 EST 1985
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5518539
Pilot study of combination 5-fluorouracil, cisdiamminedichloroplatinum II, and radiation therapy for grade III and IV astrocytomas
Journal Article
·
Thu Oct 01 00:00:00 EDT 1987
· Am. J. Clin. Oncol.; (United States)
·
OSTI ID:5849640
Hepatic Arterial Infusion Chemotherapy Using Fluorouracil Followed by Systemic Therapy Using Oxaliplatin Plus Fluorouracil and Leucovorin for Patients with Unresectable Liver Metastases from Colorectal Cancer
Journal Article
·
Wed Jul 15 00:00:00 EDT 2009
· Cardiovascular and Interventional Radiology
·
OSTI ID:21428503