Profound radiosensitivity in leukemic T-cell lines and T-cell-type acute lymphoblastic leukemia demonstrated by sodium (51Cr)chromate labeling
Radiation sensitivity was determined by measuring spontaneous release from /sup 51/Cr-labeled cells in various lymphoid cell populations. Among six leukemia T-cell lines originating from acute lymphoblastic leukemia, four such lines were found to be highly radiosensitive. In contrast, two of the leukemic T-cell lines and four normal control B-cell lines were not radiosensitive. Thymocytes from six patients and leukemia T-cell blasts from three patients with T-cell leukemia were likewise found to be highly radiosensitive, whereas leukemic blasts from six patients with null-cell (non-T, non-B-cell) acute lymphoblastic leukemia were not radiosensitive. Normal peripheral blood lymphocytes and mitogen-induced normal lymphoblasts were found not to be radiosensitive. The results indicate that measurement of the radiation sensitivity of acute leukemic blasts may have a therapeutic significance in coping with the heterogeneous nature of individual leukemia cases.
- Research Organization:
- New York State Dept. of Health, Buffalo
- OSTI ID:
- 6623258
- Journal Information:
- Cancer Res.; (United States), Vol. 38:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL CELLS
RADIOSENSITIVITY
CHROMIUM 51
DIAGNOSTIC USES
LEUKEMIA
THERAPY
BIOLOGICAL RADIATION EFFECTS
IN VITRO
LABELLED COMPOUNDS
SODIUM COMPOUNDS
THYMOCYTES
ALKALI METAL COMPOUNDS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CHROMIUM ISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPES
NEOPLASMS
NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
SOMATIC CELLS
USES
560122* - Radiation Effects on Cells- Internal Source- (-1987)