Modulation of erythropoietin levels by manipulation of hypercarbia. [Carbon dioxide levels in blood plasma]
Conference
·
OSTI ID:6622074
The present studies were done in order to determine if preventing the respiratory alkalosis which is known to occur with acute ''hypoxic'' stimuli would lead to alterations in plasma levels of Ep. Rats were subjected to two acute stresses, hypoxia and acute blood loss, separately and in combination, with and without the added stress of hypercarbia. Hypercarbia in all experimental groups was associated with a decrease in plasma levels of Ep. This reduction in plasma Ep with hypercarbia could not be fully explained by the higher arterial PO/sub 2/'s or P50's of the hypercarbic rats. Hypercarbia may have indirectly suppressed Ep production by increasing blood flow to the site of Ep production. Alternatively, the cell of origin of EP could be sensitive to changes in pH and/or pCO/sub 2/. It was further demonstrated that neither the onset nor the degree of reticulocytosis could be predicted by the plasma Ep levels. It is likely that the removal of red blood cells lead to a decrease in marrow transit time with the early emergence of reticulocytes after acute blood loss.
- Research Organization:
- Saint Elizabeth' s Hospital, Boston, MA (USA). Dept. of Medicine; Tufts Univ., Boston, MA (USA). School of Medicine; Brookhaven National Lab., Upton, NY (USA)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- EY-76-C-02-0016
- OSTI ID:
- 6622074
- Report Number(s):
- BNL-24647; CONF-7806105-1
- Country of Publication:
- United States
- Language:
- English
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Tue Jul 01 00:00:00 EDT 1975
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·
OSTI ID:7196821
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
DISEASES
ERYTHROPOIETIN
HEMORRHAGE
MAMMALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PH VALUE
RATS
RODENTS
SYMPTOMS
SYNTHESIS
VARIATIONS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ABUNDANCE
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
DISEASES
ERYTHROPOIETIN
HEMORRHAGE
MAMMALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PH VALUE
RATS
RODENTS
SYMPTOMS
SYNTHESIS
VARIATIONS
VERTEBRATES