Differential toxicity of sodium fluoroacetate for liver, kidney and testis in the rat
Technical Report
·
OSTI ID:6620752
This problem attempted to correlate selected biochemical responses with accompanying histologic changes seen in the testis, kidney, and liver of rats receiving NaFAc in their water supply. Groups of rats were placed on special low fluoride rat chow and distilled water for one week after which time FAc was added to the drinking water in concentrations of 20, 6.6, and 2.2 ppM NaFAc. Animals were sacrificed daily from each dosage group through 7 days. All remaining rats were then changed to distilled water and sacrificed at intervals during the succeeding 21 days. Growth rates were decreased during the early part of treatment in all dosage groups, but the general growth curves indicated an adaptation to the effects of the toxin. ATP and citrate concentrations in the liver were not significantly affected. In the kidney, there were transient increases in citrate concentration in the 20 and 6.6 ppM group but not in the 2.2 ppM group. Renal ATP levels were variable, but not significantly decreased. Histologic damage in the liver and kidney was not evident. The most striking changes seen were encountered in the testis. Organ weight was significantly decreased by the seventh day of treatment in the 20 and 6.6 ppM groups, and remained so throughout the 21 day post-treatment period.
- Research Organization:
- Rochester Univ., NY (USA)
- DOE Contract Number:
- EY-76-C-02-3490
- OSTI ID:
- 6620752
- Report Number(s):
- UR-3490-1412
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ANIMALS
ATP
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID SALTS
CITRATES
DIGESTIVE SYSTEM
FLUORINE COMPOUNDS
GLANDS
GONADS
HALOGEN COMPOUNDS
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MORPHOLOGICAL CHANGES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
TESTES
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ANIMALS
ATP
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID SALTS
CITRATES
DIGESTIVE SYSTEM
FLUORINE COMPOUNDS
GLANDS
GONADS
HALOGEN COMPOUNDS
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MORPHOLOGICAL CHANGES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
TESTES
TOXICITY
VERTEBRATES