Enhancement of radiopharmaceutical excretion by chemical interventions

Conference · Fri Jan 01 04:00:00 EST 1982

OSTI ID:6620601

Oster, Z H; Som, P; Brill, A B; Sacker, D F; Atkins, H L

The goal was to find methods of decreasing the radiation dose after radionuclide studies, by giving a compound that will increase the rate of excretion of the radionuclide. Sprague - 1 Dawley rats were given Tc-99m pertechnetate, Ga-67 citrate or Tl-201 chloride intravenously followed at intervals of 1 to 24 hours by one of the following compounds: desferroxamine (DFO), 2,3-dimercapto-1-propanol (BAL), triethylene tetraamine hexaacetic acid (TETHA), stannous tartarate, bleomycin (BLEO), 2,3-dimercaptosuccinic acid (DMSA), diethylene-triaminepentaacetic acid (DTPA), DTPA+SnCl.2H/sub 2/O, dihydroxybenzoic acid (DHB), and ferric-cyanoferrate (IT)(Prussian blue, PB). All the agents except PB are chelators. Some of these agents enhance excretion through the urinary tract (DFO), while most are excreted through the bile. PB was shown to increase Cs excrection through the G.I. tract. (ACR)

• Research Organization: Brookhaven National Lab., Upton, NY (USA); State Univ. of New York, Stony Brook (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6620601
• Report Number(s): BNL-30628; CONF-820804-4; ON: DE83003217
• Country of Publication: United States
• Language: English

Related Subjects

560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CHELATING AGENTS
CLEARANCE
DATA
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
EXPERIMENTAL DATA
FERRATES
GALLIUM 67
GALLIUM ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NITROGEN COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
RADIATION PROTECTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES