Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6620005

Cherry, S R; Carnochan, P; Babich, J W; Serafini, F; Rowell, N P; Watson, I A ^[1]

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1. Royal Marsden Hospital, Sutton (England)

Rubidium-81 (t1/2 = 4.58 hr) was investigated as a tumor perfusion tracer in the VX2 carcinoma implanted into rabbit thigh muscle using a large-area, multiwire proportional chamber positron emission tomography (PET) system. Perfusion was determined using the arterial reference sample method, and the results from PET imaging were compared with postmortem tissue sampling. Absolute quantitation of tumor perfusion was achieved using external probes to estimate local extraction fraction. Redistribution of rubidium-81 (81Rb) was investigated using a dual-tracer technique. Average perfusion was found to be 13.5 and 3.7 ml/min/100 g in tumor and normal muscle, respectively. The extraction fraction as estimated from a two-compartment model ranged from 0.94 to 1.00. No significant redistribution of 81Rb was observed in these tissues. Nine patients with malignancies were studied using 81Rb and PET. Tumor perfusion in four patients with carcinoma of the breast was elevated by a factor of 1.8 (range 1.2-2.3) compared to contralateral normal breast.

• OSTI ID: 6620005
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:8; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EXPERIMENTAL NEOPLASMS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAMMARY GLANDS
MAN
MINUTES LIVING RADIOISOTOPES
MUSCLES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERFUSED TISSUES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RABBITS
RADIOISOTOPES
RUBIDIUM 81
RUBIDIUM ISOTO
TISSUES
TOMOGRAPHY
TUMOR CELLS
VERTEBRATES