Effect of tracheal insufflation of deferoxamine on acute ozone toxicity in rats
Journal Article
·
· Journal of Laboratory and Clinical Medicine; (United States)
OSTI ID:6617735
- Univ. of California, Davis (United States)
To test the hypothesis that deferoxamine (DFO) may protect the lung against the acute toxicity of ozone (O3), male Sprague-Dawley rats (250 to 300 gm) were tracheally insufflated before exposure to O3 (2 ppm for 4 hours) with DFO (25 mg/kg), ferric-DFO, or sterile water. Measurements of bronchoalveolar lavage fluid (BALF) protein, ascorbate, hydrogen peroxide, and lipid hydroperoxides were made immediately after O3 exposure and 12 and 24 hours later. DFO (25 mg/kg) decreased BALF protein concentration (p < 0.05) and was associated with higher BALF ascorbate concentrations (p < 0.01) in O3-exposed animals. Ferric-DFO did not show these protective effects. No peroxides were found in BALF from any control or O3-exposed animals (detection limit: H2O2, 1 pmol; lipid hydroperoxides, 0.3 pmol). Higher DFO doses (50 mg/kg and 100 mg/kg) did not decrease BALF protein concentration immediately after O3 exposure or 12 hours later. Indeed, the highest dose was toxic to O3-exposed animals. Although DFO is able to protect against O3-induced lung damage in rats, apparently by chelating iron, its effect dose range appears to be narrow.
- OSTI ID:
- 6617735
- Journal Information:
- Journal of Laboratory and Clinical Medicine; (United States), Journal Name: Journal of Laboratory and Clinical Medicine; (United States) Vol. 121:3; ISSN JLCMAK; ISSN 0022-2143
- Country of Publication:
- United States
- Language:
- English
Similar Records
N-Acetylcysteine and deferoxamine reduce pulmonary oxidative stress and inflammation in rats after coal dust exposure
Preconditioning induced by gentamicin protects against acute kidney injury: The role of prostaglandins but not nitric oxide
Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation
Journal Article
·
Mon Oct 31 23:00:00 EST 2005
· Environmental Research
·
OSTI ID:20700974
Preconditioning induced by gentamicin protects against acute kidney injury: The role of prostaglandins but not nitric oxide
Journal Article
·
Sun May 15 00:00:00 EDT 2011
· Toxicology and Applied Pharmacology
·
OSTI ID:21535300
Effect of dietary vitamin E level on the biochemical response of rat lung to ozone inhalation
Journal Article
·
Thu Dec 31 23:00:00 EST 1987
· Drug Nutr. Interact; (United States)
·
OSTI ID:6251727
Related Subjects
551000* -- Physiological Systems
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
CHELATING AGENTS
DEFEROXAMINE
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
LAVAGE
MAMMALS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
OZONE
PEROXIDES
RATS
RESPIRATORY SYSTEM DISEASES
RODENTS
TOXICITY
VERTEBRATES
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
CHELATING AGENTS
DEFEROXAMINE
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
LAVAGE
MAMMALS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
OZONE
PEROXIDES
RATS
RESPIRATORY SYSTEM DISEASES
RODENTS
TOXICITY
VERTEBRATES