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Preparation and properties of antitumor monoclonal antibodies labeled with metallic radionuclides indium-111, gallium-67, and technetium-99m

Journal Article · · NCI Monogr.; (United States)
OSTI ID:6616464
; ; ; ; ; ; ; ; ;
In this study, metallic radionuclides such as /sup 111/In, /sup 67/Ga, or /sup 99m/Tc produced clear visualization in scintigraphic imaging of tumors; they have short half-lives and can easily be used in the radiolabeling of monoclonal antibodies by using bifunctional chelating agents. Under selected conditions, these radiolabeled antibodies were stable both in vitro and in vivo with no loss of the antigen-binding activity. Despite high background imaging of the liver and kidney, transplanted tumors in nude mice were clearly visualized with /sup 111/In-, /sup 67/Ga-, and /sup 99m/Tc-labeled antibodies at 6, 24, or 48 hours after the injection. Although tissue distribution in the liver, kidney, and bone was different among radionuclides used for the labeling, all tumor to blood ratios were higher than those of radioiodinated monoclonal antibodies. These results provide a good basis for studies of the clinical usefulness of /sup 111/In-, /sup 67/Ga-, and /sup 99m/Tc-labeled monoclonal antibodies for radioimmunoimaging.
Research Organization:
Kyoto Univ. Faculty of Medicine, Japan
OSTI ID:
6616464
Journal Information:
NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 3; ISSN NCIME
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLING
LIVER
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES