Reassignment of the human ARH9 RAS-related gene to chromosome 1p13-p21
Journal Article
·
· Genomics; (United States)
- St. Jude Children's Research Hospital, Memphis, TN (United States) Univ. of Tennessee, Memphis (United States)
- St. Jude Children's Research Hospital, Memphis, TN (United States)
- Thomas Jefferson Univ., Philadelphia, PA (United States)
The human ARH9 gene (originally rhoC), a member of the RAS gene superfamily, was initially isolated on the basis of cross-hybridization with a RAS-related cDNA from the marine snail Aplysia. The ARH9 gene locus was previously assigned to the telomeric region of chromosome 5q by isotopic chromosomal in situ hybridization and Southern analysis of somatic cell hybrid DNAs; the gene was noted to cosegregate with the CSF1 gene locus in human-rodent somatic cell hybrids carrying partial chromosomes 5, together with other human chromosomes. With the recent reassignment of the human CSF1 locus to chromosome 1, region p13-p21, it seemed important to reexamine the localization of the ARH9 gene, since it segregates 100% concordantly with the CSF1 locus in hybrid cells. Results of the investigation demonstrate that the ARH9 locus is also present in hybrids retaining chromosome 1, but not 5. Using hybrids carrying partial 1p, the authors mapped the ARH9 locus relative to other 1p loci, localizing the gene to the region 1p13-p31. Fluorescence in situ hybridization to metaphase chromosomes with a genomic ARH9 clone refined the gene's localization to chromosome 1, bands p13-p21. 19 refs., 1 fig., 1 tab.
- OSTI ID:
- 6616332
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:3; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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