Constitutional Ip36 deletion in a child with neuroblastoma

Journal Article · Thu Dec 31 23:00:00 EST 1992 · American Journal of Human Genetics; (United States)

OSTI ID:6615985

Biegel, J A; Zackai, E H; Scher, C D; Emanuel, B S ^[1]; White, P S; Marshall, H N; Fujimori, Minoru; Brodeur, G M ^[2]

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1. Children's Hospital, Philadelphia, PA (United States) Univ. of Pennsylvania, Philadelphia (United States)
2. Washington Univ., St. Louis, MO (United States)

The authors describe a child with dysmorphic features, as well as developmental and growth delay, who developed neuroblastoma at 5 mo of age. Cytogenetic analysis of blood lymphocytes revealed an interstitial deletion of 1p36.1 [r arrow] 1p36.2, which was apparent only with high-resolution banding. Molecular analysis with a collection of polymorphic DNA probes for 1p confirmed an interstitial deletion involving subbands of 1p36. Deletions of this region are a common finding in neuroblastoma cells from patients with advanced stages of disease. Therefore, these results (a) suggest that constitutional deletion of this region predisposed the patient to the development of neuroblastoma and (b) support the localization of a neuroblastoma tumor-suppressor locus to 1p36. 48 refs., 2 figs.

• OSTI ID: 6615985
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 52:1; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BANDING TECHNIQUES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
CYTOLOGICAL TECHNIQUES
DISEASES
DNA
DNA HYBRIDIZATION
GROWTH
HUMAN CHROMOSOMES
HYBRIDIZATION
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROBES
SARCOMAS
SOMATIC CELLS