Radiotherapy of the R1H-tumor: Dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators

Journal Article · Fri Jan 15 00:00:00 EST 1993 · International Journal of Radiation Oncology, Biology and Physics; (United States)

DOI:https://doi.org/10.1016/0360-3016(93)90349-Z· OSTI ID:6614806

Kleineidam, M; Guthoff, R; Schiller, F; Chumbley, L; Beck-Bornholdt, H P ^[1]

---

1. Univ. of Hospital Hamburg-Eppendorf (Germany)

The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr). This system is a biological model for treatment of uveal melanoma.

• OSTI ID: 6614806
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (United States), Vol. 25:2; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
EYES
RADIOTHERAPY
MELANOMAS
RUTHENIUM 106
DOSE RATES
BIOLOGICAL MODELS
OXYGEN
TIME DEPENDENCE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CARCINOMAS
DISEASES
ELEMENTS
EPITHELIOMAS
EVEN-EVEN NUCLEI
FACE
HEAD
INTERMEDIATE MASS NUCLEI
ISOTOPES
MEDICINE
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
RUTHENIUM ISOTOPES
SENSE ORGANS
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)