Genetic defect causing familial Alzheimer's disease maps on chromosome 21

Journal Article · Fri Feb 20 04:00:00 EST 1987 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.2880399· OSTI ID:6614039

George-Hyslop, P H; Tanzi, R E; Polinsky, R J; Haines, J L; Nee, L; Watkins, P C; Myers, R H; Feldman, R G; Pollen, D; Drachman, D; Growdon, J

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several families have been described in which Alzheimer's disease is caused by an autosomal dominant gene defect. The chromosomal location of this defective gene has been discovered by using genetic linkage to DNA markers on chromosome 21. The localization on chromosome 21 provides an explanation for the occurrence of Alzheimer's disease-like pathology in Down syndrome. Isolation and characterization of the gene at this locus may yield new insights into the nature of the defect causing familial Alzheimer's disease and possibly, into the etiology of all forms of Alzheimer's disease.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 6614039
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 235; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
DATA
DISEASES
DNA
ETIOLOGY
EXPERIMENTAL DATA
GENES
GENETIC MAPPING
INFORMATION
MAPPING
MENTAL DISORDERS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS