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Field and laboratory studies of the etiology of liver neoplasms in marine fish from Puget Sound

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.87715· OSTI ID:6610463
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A series of field studies was conducted between 1979 and 1985 in Puget Sound, Washington State, to investigate etiological relationships between prevalences of hepatic neoplasms in bottom-dwelling marine fish species, with emphasis on English sole (Parophrys vetulus), and concentrations of toxic chemicals in sediments and affected fish. Statistically significant correlations have been found between the prevalences of hepatic neoplasms in English sole and the following parameters: (1) sediment concentrations of aromatic hydrocarbons, and (2) concentrations of the metabolites of aromatic compounds in the bile of affected sole. A significant difference was also found between the relative concentrations of aromatic free radicals in the liver microsomes of English sole with liver lesions compared to sole without liver lesions. Laboratory studies designed to evaluate the etiology of the liver neoplasms in English sole have also yielded evidence that is consistent with the view that high molecular weight aromatic hydrocarbons, e.g., benzo(a)pyrene (BaP), are hepatocarcinogens in English sole. The current status of a series of long-term (up to 18 months) exposures of English sole and rainbow trout (Salmo gairdneri) to selected fractions of Puget Sound sediment extracts, enriched with aromatic hydrocarbons and nitrogen-containing aromatic compounds, and to individual carcinogens (e.g., BaP) is discussed.
Research Organization:
National Oceanic and Atmospheric Administration (NOAA), Seattle
OSTI ID:
6610463
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 71; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISEASES
ETIOLOGY
FIELD TESTS
FISHES
GLANDS
HYDROCARBONS
LIVER
MICROSOMES
MOLECULAR WEIGHT
NEOPLASMS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PACIFIC OCEAN
POLYCYCLIC AROMATIC HYDROCARBONS
PUGET SOUND
SEAS
SEDIMENTS
SURFACE WATERS
TESTING
TROUT
VERTEBRATES