Localization of metastases from medullary thyroid carcinoma using different methods

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Henry Ford Hospital Medical Journal; (USA)

OSTI ID:6609440

Cabezas, R C; Berna, L; Estorch, M; Carrio, I; Garcia-Ameijeiras, A

We analyzed the efficiency of three different noninvasive methods in the localization of recurrent medullary thyroid carcinoma (MTC). Nine patients (six females and three males) with biochemical evidence of disease after primary surgery were subjected to {sup 131}I anti-carcinoembryonic antigen (anti-CEA) antibody, {sup 131}I meta-iodo-benzylguanidine (MIBG), and computed tomography. Another female patient, in biochemical remission for six years after initial surgery, was also studied using the same methods. Three of the ten patients had negative results with all three methods (including the patient in remission). The other seven patients showed abnormal uptake of labeled anti-CEA antibody in various localizations; only two of these patients had a corresponding pathological image by computed tomography and only one by {sup 131}I MIBG. These preliminary results suggest that {sup 131}I anti-CEA scanning may be the most sensitive noninvasive method for the localization of MTC recurrences.

• OSTI ID: 6609440
• Journal Information: Henry Ford Hospital Medical Journal; (USA), Journal Name: Henry Ford Hospital Medical Journal; (USA) Vol. 37:3-4; ISSN HFHJA; ISSN 0018-0416
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CALCITONIN
CARCINOMAS
CEA
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EFFICIENCY
ENDOCRINE GLANDS
FRENCH ORGANIZATIONS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
METASTASES
MONOCLONAL ANTIBODIES
NATIONAL ORGANIZATIONS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
THYROID
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES