Measurement of infarct size using single photon emission computed tomography and /sup 99m/Tc pyrophosphate: a description of the method and comparison with patient prognosis

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/0002-9149(82)90316-2· OSTI ID:6607366

Holman, B L; Goldhaber, S Z; Kirsch, C M; Polak, J F; Friedman, B J; English, R J; Wynne, J

The application of dual tracer transaxial emission computed tomography of the heart was studied with use of /sup 99m/Tc pyrophosphate and /sup 99m/Tc-labeled red blood cells for measuring infarct size in 20 patients with acute myocardial infarction and 10 without infarction. Imaging was performed with a standard gamma camera and with a multidetector transaxial emission computed tomographic body scanner 3 hours after injection of /sup 99m/Tc pyrophosphate. Immediately after the scanning procedure, /sup 99m/Tc pertechnetate was injected to label red blood cells, and the scanning protocol was repeated. /sup 99m/Tc pyrophosphate was detected in the anterior wall with involvement of the interventricular septum or lateral wall in patients with electrocardiographic criteria for anterior infarction, whereas uptake was detected in the diaphragmatic left ventricular wall with involvement of the posterior, posteroseptal or posterolateral left ventricle or of the right ventricle in patients with electrocardiographic criteria for inferior or posterior infarction. Infarct size measured from transaxial images ranged from 14.0 to 117.0 g in weight. There was a direct relation between infarct size and patient prognosis in that, of the 13 patients with infarct greater than 40 g, 11 (85 percent) had complications, whereas only 2 (29 percent) of 7 patients with an infarct less than 40 g had complications during a follow-up period averaging 17.8 months (p less than 0.05).

• Research Organization: Department of Radiology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA
• OSTI ID: 6607366
• Journal Information: Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 50:3; ISSN AJCDA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
ELECTROCARDIOGRAMS
EMISSION COMPUTED TOMOGRAPHY
ERYTHROCYTES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES