Excision repair in xeroderma pigmentosum group C cells is regulated differently in transformed cells and primary fibroblasts

Journal Article · Fri Oct 14 00:00:00 EDT 1988 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/S0006-291X(88)80878-7· OSTI ID:6606205

Cleaver, J E

Excision repair in xeroderma pigmentosum group C cells occurs at about 20-30% of normal levels. In confluent fibroblasts a unique characteristic of this low repair is that it is clustered, representing very efficient repair in a small region of the genome. In SV40-transformed fibroblasts and Epstein-Barr virus-transformed lymphocytes of complementation group C, however, excision repair is randomly distributed. This may be a consequence of the high rate of proliferation of both of these cell types, because random repair is also observed in rapidly proliferating group C fibroblasts. The distribution of sites that can be mended in group C cells, therefore, varies according to the transformed and proliferative state of the cells, demonstrating that transformed cells do not always exhibit repair characteristics identical to those of primary fibroblasts.

• Research Organization: Univ. of California, San Francisco (USA)
• OSTI ID: 6606205
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Vol. 156:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
FIBROBLASTS
CELL PROLIFERATION
LYMPHOCYTES
XP CELLS
EXCISION REPAIR
CELL CULTURES
DNA REPLICATION
XERODERMA PIGMENTOSUM
ANIMAL CELLS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
LEUKOCYTES
MATERIALS
NUCLEIC ACID REPLICATION
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
550200* - Biochemistry