Alterations in in-vivo benzodiazepine-receptor binding of C-11-Ro15-1788 (flumazepil)

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6604656

Yamasaki, T; Inoue, O; Shinoto, H; Ito, T; Hashimoto, K; Suzuki, K; Tateno, Y

Alterations of the central benzodiazepine - receptor function caused by the change of physiological or psychological conditions, were recognized in both animal and human studies. Before the human study, animal experiments using tritiated Ro15-1788 were carried out. The stress was produced by forcing the mice to swim in a water-basin at 16/sup 0/C for 5 min. Within 3 min after the forced swimming, the tracer was injected. Brain radioactivities in stress-loaded mice increased over a period of 15 min after the intra-venous injection of tracers, while brain activities of carrier-added tracer decreased. In human study, approximately 5 mCi of C-11-Ro15-1788, which specific activity is 0.3-1.0 Ci/..mu..mol, were intravenously injected to each case. Measurements of the brain activity were performed using positron-CT, with blood sample collection. 31 human studies were performed on. Cerebral cortex time activity curves in several volunteers in nervous and stressful state, showed the same pattern to that in the stress-loaded animal experiment. It is important that the significant different time course of cerebral activity after the injection of labelled Ro15-1788, was observed in stressful state, compared with control, in both human and animal study. From these results, it will be concluded the positron CT study using /sup 11/C-Ro15-1788 will become a new technic to detect the change of psychological conditions in human brain and to diagnose some kind of neuropsychiatric disease.

• Research Organization: Div. of Clinical Research, National Institute of Radiological Sciences, Chiba
• OSTI ID: 6604656
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550101 -- Behavioral Biology-- Tracer Techniques
550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANATOMY
ANIMALS
ANTICONVULSANTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL STRESS
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CEREBRAL CORTEX
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
EXERCISE
IN VIVO
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
MEMBRANE PROTEINS
MENTAL DISORDERS
MICE
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PROTEINS
PSYCHOLOGY
RADIOISOTOPES
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
TIME DEPENDENCE
TOMOGRAPHY
TRACER TECHNIQUES
USES
VERTEBRATES