Quantitative measurement of feline colonic transit

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Am. J. Physiol.; (United States)

OSTI ID:6604322

Krevsky, B; Somers, M B; Maurer, A H; Malmud, L S; Knight, L C; Fisher, R S

Colonic transit scintigraphy, a method for quantitatively evaluating the movement of the fecal stream in vivo, was employed to evaluate colonic transit in the cat. Scintigraphy was performed in duplicate in five cats and repeated four times in one cat. After instillation of an 111In marker into the cecum through a surgically implanted silicone cecostomy tube, colonic movement of the instillate was quantitated for 24 h using gamma scintigraphy. Antegrade and retrograde motion of radionuclide was observed. The cecum and ascending colon emptied rapidly, with a half-emptying time of 1.68 +/- 0.56 h (mean +/- SE). After 24 h, 25.1 +/- 5.2% of the activity remained in the transverse colon. The progression of the geometric center was initially rapid, followed later by a delayed phase. Geometric center reproducibility was found to be high when analyzed using simple linear regression (slope = 0.92; r = 0.73; P less than 0.01). Atropine (0.1 mg/kg im) was found to delay cecum and ascending colon emptying and delay progression of the geometric center. These results demonstrate both 1) the ability of colonic transit scintigraphy to detect changes in transit induced by pharmacological manipulation and 2) the fact that muscarinic blockade inhibits antegrade transit of the fecal stream. We conclude that feline colonic transit may be studied in a quantitative and reproducible manner with colonic transit scintigraphy.

• Research Organization: Temple Univ. School of Medicine, Philadelphia, PA (USA)
• OSTI ID: 6604322
• Journal Information: Am. J. Physiol.; (United States), Vol. 255
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ATROPINE
BIOLOGICAL EFFECTS
LARGE INTESTINE
SCINTISCANNING
CATS
DYNAMIC FUNCTION STUDIES
FECES
INDIUM 111
REGRESSION ANALYSIS
ALKALOIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MATHEMATICS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOLYTICS
RADIOISOTOPE SCANNING
RADIOISOTOPES
STATISTICS
VERTEBRATES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics