Drinking-water criteria document for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Draft report
Technical Report
·
OSTI ID:6603645
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is one of the most toxic and environmentally stable tricyclic aromatic compounds belonging to chlorinated dibenzo-p-dioxins. 2,3,7,8-TCDD has been demonstrated to be teratogenic in rats, mice and rabbits, and feticidal in monkeys. The major toxic signs and terata observed were cleft palate in mice, edema, hemorrhage, and kidney anomalies in rats and extra ribs in rabbits. Some epidemiological studies have indicated a possible teratogenic effect in humans, but the evidence is not sufficient to reach a firm conclusion.
- Research Organization:
- Environmental Protection Agency, Cincinnati, OH (USA). Office of Environmental Criteria and Assessment
- OSTI ID:
- 6603645
- Report Number(s):
- PB-90-215294/XAB; ECAO-CIN--405
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
DIGESTIVE SYSTEM
DIOXIN
DRINKING WATER
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LIPIDS
LIVER
MAMMALS
MAN
METABOLISM
MICE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
RABBITS
RATS
REPRODUCTION
RODENTS
STRUCTURE-ACTIVITY RELATIONSHIPS
TERATOGENESIS
TOXICITY
VERTEBRATES
WATER
WATER POLLUTION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
DIGESTIVE SYSTEM
DIOXIN
DRINKING WATER
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LIPIDS
LIVER
MAMMALS
MAN
METABOLISM
MICE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
RABBITS
RATS
REPRODUCTION
RODENTS
STRUCTURE-ACTIVITY RELATIONSHIPS
TERATOGENESIS
TOXICITY
VERTEBRATES
WATER
WATER POLLUTION