Misonidazole and radiotherapy to treat malignant glioma: a Phase II trial of the radiation therapy oncology group

Journal Article · Wed Dec 31 23:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90062-6· OSTI ID:6603383

Carabell, S C ^[1]; Bruno, L A; Weinstein, A S; Richter, M P; Chang, C H; Weiler, C B; Goodman, R L

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1. Univ. of Pennsylvania School of Medicine, Philadelphia

Fifty-four patients with Grade III or IV malignant glioma were treated with the hypoxic-cell radiosensitizer, misonidazole, and radiation therapy (RT) in a Pmae II trial of the Radiation Therapy Oncology Group (RTOG). The median survival was 39 weeks. Toxicity was acceptable. Almost all toxicities were reversible and self-limited. There were no significant changes in hematologic, hepatic or renal parameters. The median survival obtained is similar to the results with conventional radiotherapy. A Phase III trial is under way comparing standard radiation and BCNU chemotherapy (1,3-bis (2-chloroethyl)-1-nitrosurea) with sensitized radiation and chemotherapy (RT + misonidazole + BCNU). Additive toxicity between misonidazole and BCNU was not observed in a pilot group.

• OSTI ID: 6603383
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
DISEASES
DOSES
DRUGS
EXTERNAL IRRADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MEDICINE
MISONIDAZOLE
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NITROSO COMPOUNDS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SURGERY
SURVIVAL CURVES
THERAPY
TOXICITY