Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics. Annual report, 30 September 1985-29 September 1986

Technical Report · Sat Nov 01 04:00:00 EST 1986

OSTI ID:6602467

Riviere, J E; Carver, M P; Monteiro-Riviere, N A; Bowman, K F

Interspecies comparisons of cutaneous anatomy and physiology suggest that the weanling pig is a suitable surrogate for human skin; however, very few investigations of percutaneous absorption phenomena have been conducted in pigs. This study examined the radiolabel excretion patterns after intravenous (IV) and topical administration of six /sup 14/C-labeled compounds in weanling Yorkshire sows. These data were required as a baseline to compare xenobiotic absorption in the isolated perfused procine skin flap (IPPSF) fully described in the first Annual Report (Riviere, J. E., Bowman, K. F., and Monteiro-Riviere, N. A., Development of In Vitro Isolated Perfused Porcine Skin Flaps for Study of Percutaneous Absorption of Xenobiotics, USAMRDC, DAMD17-84-C-4103, November 1, 1986).

• Research Organization: North Carolina State Univ., Raleigh (USA). Lab. of Toxicokinetics
• OSTI ID: 6602467
• Report Number(s): AD-A-198960/7/XAB
• Country of Publication: United States
• Language: English

Related Subjects

550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANATOMY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON 14
CARBON ISOTOPES
DISEASES
DOCUMENT TYPES
DOMESTIC ANIMALS
EVEN-EVEN NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
NUCLEI
PHARMACOLOGY
PHYSIOLOGY
PROGRESS REPORT
RADIOISOTOPES
SKIN ABSORPTION
SKIN DISEASES
SWINE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
XENOBIOTICS
YEARS LIVING RADIOISOTOPES