Calculation of portal contribution to hepatic blood flow with 99mTc-microcolloids. A noninvasive method to diagnose liver graft rejection

Journal Article · Tue Nov 01 00:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:6601824

Martin-Comin, J; Mora, J; Figueras, J; Puchal, R; Jaurrieta, E; Badosa, F; Ramos, M

The portal contribution (PC) to hepatic blood flow was calculated in 13 liver graft patients and 13 normal volunteers. The method is based on the quantification and normalization of the liver and spleen activity after the administration of 7 mCi (259 MBq) of 99mTc microcolloid. Forty examinations were performed in liver grafts and 13 in normal subjects. The PC was significantly higher in normal native liver (64.0 +/- 3.0%) than in functioning grafts (58.8 +/- 3.1%). In acutely rejecting patients, PC was significantly lower (52.4 +/- 2.0%) than in functioning grafts and similar to that observed in cholangitis (53.5 +/- 0.7%). The PC increases again once rejection has resolved (57.3 +/- 2.6%). During hepatitis post-transplant PC values (59.7 +/- 3.4%) were similar to those observed in functioning grafts. Overall, PC values over 55% are very unlikely to be due to rejection.

• Research Organization: Hospital Universitari de Bellvitge Princeps d'Espanya, Barcelona (Spain)
• OSTI ID: 6601824
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GRAFT-HOST REACTION
DIAGNOSIS
LIVER
BLOOD FLOW
COLLOIDS
ISOMERIC NUCLEI
PORTAL SYSTEM
SPLEEN
TECHNETIUM 99
TRANSPLANTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DISPERSIONS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
VEINS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics