Lethality and hepatotoxicity of complex waste mixtures (journal version)

Technical Report · Fri Jan 01 04:00:00 EST 1988

OSTI ID:6601012

Simmons, J E; DeMarini, D M; Berman, E

Male F344 rats were exposed by gavage to samples of complex mixtures and evaluated 24 hours later. Seven of the 10 samples caused death at doses ranging from 1 to 5 ml/kg body wt. Eight of the 10 samples were hepatotoxic based on histopathologic evaluation; 6 were centrilobular and 2 were periportal hepatotoxicants. The waste samples exerted toxicity through different mechanisms, as indicated by differences in the severity and lobular location of the tissue damage. With histopathological evaluation as the criterion, relative liver weight was the single best indicator of hepatotoxicity. Exposure to several of the waste samples increased serum total bilirubin and serum enzyme activities of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase, and ornithine carbamyl transferase. As a battery, but not individually, the serum indicators separated the 8 hepatotoxic samples from the 2 nonhepatotoxic samples. In general, the hepatotoxicity of the waste samples did not appear to be readily predicted from (partial) chemical characterization data.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 6601012
• Report Number(s): PB-89-109367/XAB; EPA-600/J-88/117
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
CHEMICAL ANALYSIS
DIGESTIVE SYSTEM
DISPERSIONS
DOSES
GLANDS
HAZARDOUS MATERIALS
HISTOLOGY
INDUSTRIAL WASTES
LABORATORY ANIMALS
LETHAL DOSES
LIVER
MATERIALS
MIXTURES
ORAL ADMINISTRATION
ORGANS
TOXIC MATERIALS
TOXICITY
WASTES