Iron, lead, and cobalt absorption: similarities and dissimilarities

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-166-41025· OSTI ID:6594071

Barton, J C; Conrad, M E; Holland, R

Using isolated intestinal segments in rats, the absorption of iron, lead, and cobalt was increased in iron deficiency and decreased in iron loading. Similarly, the absorption of these metals was decreased in transfusional erythocytosis, after intravenous iron injection and after parenteral endotoxin injection. Acute bleeding or abbreviated intervals of dietary iron deprivation resulted in increased iron absorption from isolated intestinal segments and in intact animals, while the absorption of lead and cobalt was unaffected. These results suggest that the specificity of the mucosal metal absorptive mechanism is either selectively enhanced for iron absorption by phlebotomy or brief periods of dietary iron deprivation, or that two or more mucosal pathways for iron absorption may exist.

• Research Organization: Univ. of Alabama, Birmingham
• OSTI ID: 6594071
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 166:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BLOOD
BLOOD CELLS
BODY FLUIDS
COBALT
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
ERYTHROCYTES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HEAVY NUCLEI
HEMIC DISEASES
HEMORRHAGE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINAL ABSORPTION
IRON
IRON 59
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEAD
LEAD 210
LEAD ISOTOPES
LIQUID SCINTILLATORS
MAMMALS
MATERIALS
METABOLISM
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUTRITIONAL DEFICIENCY
ODD-ODD NUCLEI
PATHOLOGICAL CHANGES
PHOSPHORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
SYMPTOMS
TRACER TECHNIQUES
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
WHOLE-BODY COUNTING
YEARS LIVING RADIOISOTOPES