Genetic and animal toxicity testing of SRC-I products, intermediates, and waste materials: Final report: Appendix C, Lifetime inhalation carcinogenicity studies of first-stage solid product (SRC solids)

Technical Report · Sun Nov 01 04:00:00 EST 1987

OSTI ID:6592998

Drozdowicz, B Z; Kelly, C M

We have completed an extensive program to investigate the toxicity---including mutagenic, carcinogenic, and teratogenic potential---of SRC-I (Solvent Refined Coal-I) products, along with selected intermediates and waste materials, as represented by the SRC-I Design Baseline. The original primary objective of the toxicology program was to produce data that could be used for four main purposes: to support design of programs to ensure workers' health and safety; to help estimate environmental impacts of SRC-I technology; to support the Toxic Substances Control Act (TSCA) premanufacturing notification process for SRC-I technology; and to promote public understanding and acceptance of the potential health effects of the emerging synfuels industry. The toxicology program consists of five main elements: (1) Genetic Toxicity Evaluations; (2) Acute Animal Toxicity Evaluations; (3) Subchronic Animal Toxicity Evaluations; (4) Chronic (life-span) Animal Carcinogenicity Evaluation; (5) Quality Control/Quality Assurance (QC/QA) Monitoring and Evaluation.

• Research Organization: Air Products and Chemicals, Inc., Allentown, PA (USA)
• DOE Contract Number: AC05-84OR21446
• OSTI ID: 6592998
• Report Number(s): DOE/OR/21446-T1-App.C; ON: DE89006273
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
010900 -- Coal
Lignite
& Peat-- Environmental Aspects
016000* -- Coal
Lignite
& Peat-- Health & Safety
ANIMALS
BIOLOGICAL EFFECTS
BODY
BY-PRODUCTS
CARCINOGENESIS
CONTROL
DOCUMENT TYPES
FUELS
GENETIC EFFECTS
MAMMALS
MICE
MODIFICATIONS
MONITORING
MUTAGENESIS
ORGANS
PATHOGENESIS
PROGRESS REPORT
QUALITY CONTROL
RATS
RODENTS
SKIN
SOLVENT-REFINED COAL
TERATOGENESIS
TOXICITY
VERTEBRATES