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Clinical significance of human alpha-fetoprotein

Journal Article · · Ann. Clin. Lab. Sci.; (United States)
OSTI ID:6591718
Deviations from the normal of alpha-fetoprotein (AFP) concentrations in fetal serum, amniotic fluid, maternal serum and adult human serum can be explained by understanding the normal physiology and the pathophysiology of AFP synthesis and metabolism. AFP is the prototype of oncofetal markers. Emphasis is given to the usefulness of elevated serum AFP levels in the diagnosis and management of primary hepatomas and tumors of germ cell origin. The ability to detect neural tube defects early in gestation by monitoring maternal serum and amniotic fluid AFP concentrations is discussed.
Research Organization:
Univ. of Chicago, IL
OSTI ID:
6591718
Journal Information:
Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 8:2; ISSN ACLSC
Country of Publication:
United States
Language:
English

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