Suppression of experimental autoimmune thyroiditis in the guinea pig by pretreatment with thyroglobulin in incomplete Freund's adjuvant. [/sup 125/I tracer technique]

Journal Article · Fri Sep 01 04:00:00 EDT 1978 · Cell. Immunol.; (United States)

DOI:https://doi.org/10.1016/0008-8749(78)90104-1· OSTI ID:6589842

Braley-Mullen, H; Sharp, G C; Kyriakos, M; Hayes, N; Dunn, C; Jepsen, P; Sanders, R D

Pretreatment of Strain 2 and Strain 13 guinea pigs with guinea pig thyroglobulin (GPTG)/sup 2/ in incomplete Freund's adjuvant (IFA) reduced both the incidence and severity of experimental autoimmune thyroiditis (EAT) in animals subsequently challenged with GPTG in complete Freund's adjuvant (CFA). Antithyroglobulin antibody titers were reduced by pretreatment with GPTG in IFA in some, but not all, experiments while delayed hypersensitivity to GPTG was not affected. The suppressive effect induced by antigen pretreatment was transferrable by lymphoid cells but not by serum from pretreated animals.

• Research Organization: Univ. of Missouri, Columbia
• OSTI ID: 6589842
• Journal Information: Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 39:2; ISSN CLIMB
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
GLOBULINS
GUINEA PIGS
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RODENTS
SOMATIC CELLS
THYROGLOBULIN
THYROIDITIS
TRACER TECHNIQUES
VERTEBRATES