A 6. 5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22

Journal Article · Sat Jan 01 04:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1010· OSTI ID:6588808

Vetrie, D; Kendall, E; Coffey, A; Hassock, S; Collins, J; Todd, C; Bobrow, M; Bentley, D R ^[1]; Lehrach, H ^[2]; Harris, A ^[3]

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1. Paediatric Research Unit, London (United Kingdom)
2. Imperial Cancer Research Fund, London (United Kingdom)
3. John Radcliffe Hospital, Oxford (United Kingdom)

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome. 45 refs., 2 figs., 2 tabs.

• OSTI ID: 6588808
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 19:1; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
BIOTECHNOLOGY
CHROMOSOMES
CLONING
DISEASES
DNA HYBRIDIZATION
DNA-CLONING
GENETIC ENGINEERING
GENETIC MAPPING
GLOBULINS
GLOBULINS-GAMMA
HEREDITARY DISEASES
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
HYBRIDIZATION
MAPPING
NUCLEIC ACID HYBRIDIZATION
ORGANIC COMPOUNDS
PROTEINS
X CHROMOSOME