Synthesis and accumulation of stress proteins in tissues of arsenite-exposed fathead minnows (Pimephales promelas)

Journal Article · Sat May 01 00:00:00 EDT 1993 · Environmental Toxicology and Chemistry; (United States)

DOI:https://doi.org/10.1897/1552-8618(1993)12[913:SAAOSP]2.0.CO;2· OSTI ID:6587266

Dyer, S D; Brooks, G L; Dickson, K L; Zimmerman, E G ^[1]; Sanders, B M ^[2]

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1. Univ. of North Texas, Denton (United States)
2. California State Univ., Long Beach (United States)

The stress protein response (SPR) is a ubiquitous, protective, and defensive mechanism that enables cells to tolerate environmental perturbations. Induction of the SPR involves the increased transcription of stress protein genes, the products of which function in protein folding, multimeric protein assembly, receptor interactions, and heme catabolism, and so forth. The potential of this response as an indicator of water quality was evaluated in gill and striated muscle tissues of fathead minnows (Pimephales promelas) exposed to a wide range of concentrations of sodium arsenite for various lengths of time. The SPR in gill was elicited rapidly, occurring by 2 h exposure at 25 mg/L. The response was tissue specific. In gill, synthesis and accumulation rates of 20-, 40-, 70-, 72-, and 74-kD proteins were significantly increased, compared to controls. In muscle, 20-, 30-, 68-, 70-, and 90-kD proteins also showed significantly increased syntheses and accumulations. Synthesis and accumulation rates of arsenite-induced proteins 20-, 70-, 72-, and 74-kD in gill were significantly correlated with mortality. However, in striated muscle, only the 70-kD was significantly correlated with mortality.

• OSTI ID: 6587266
• Journal Information: Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 12:5; ISSN 0730-7268; ISSN ETOCDK
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
ARSENIC
BIOLOGICAL STRESS
ELEMENTS
ENVIRONMENTAL QUALITY
FATHEAD MINNOW
FISHES
GILLS
METABOLISM
ORGANIC COMPOUNDS
PROTEINS
RESPIRATORY SYSTEM
SEMIMETALS
SENSITIVITY
TOXICITY
VERTEBRATES
WATER QUALITY