Dosimetry of /sup 131/I-labeled anti-ferritin in hepatoma: a model for radioimmunoglobulin dosimetry

Journal Article · Sun Mar 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90105-X· OSTI ID:6582462

Leichner, P K ^[1]; Klein, J L; Garrison, J B; Jenkins, R E; Nickoloff, E L; Ettinger, D S; Order, S E

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1. Johns Hopkins Medical Institutions, Baltimore, MD

Dosimetric studies are reported for four hepatoma patients treated with /sup 131/I-labeled anti-ferritin following combination radiation and chemotherapy. Administered activities of radiolabeled antibody ranged from 93 to 157 mCi. Studies included liver and tumor volume calculations from sequences of computerized axial tomographic (CAT) scan slices, in-vivo quantitation of radiolabeled antibody in the liver and tumor, determination of kinetic parameters of radioimmunoglubulin for liver, tumor, and the total body, and computation of dose rates (rad/hour) and dose (rad) for these tissues. Mean values of the effective half-life for radiolabeled antibody in the liver and tumor were 7.4 days and for total-body activity 3.6 days, respectively. For the four patients, the calculated /sup 131/I radiation dose for tumor tissue ranged from 1500 to 2200 rad, for liver tissue from 400 to 1000 rad, and for total-body irradiation (TBI) from 110 to 220 rad.

• OSTI ID: 6582462
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
CAT SCANNING
CHEMOTHERAPY
COMPLEXES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DOSIMETRY
EXTERNAL IRRADIATION
FERRITIN
GLOBULINS
HEPATOMAS
IMAGE PROCESSING
IMMUNOGLOBULINS
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
IRON COMPLEXES
IRRADIATION
ISOTOPES
LINERS
MEDICINE
METALLOPROTEINS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PROCESSING
PROTEINS
RADIATION DOSES
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
TOMOGRAPHY
TRANSITION ELEMENT COMPLEXES
UPTAKE
WHOLE-BODY IRRADIATION