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Imaging of acute arterial injury with /sup 111/In-labeled platelets: a comparison with scanning electron micrographs

Journal Article · · Radiology; (United States)
OSTI ID:6582027
; ; ; ; ; ; ; ; ;
The relationship between degree of acute arterial injury, extent of platelet deposition, and ability to visualize arterial injury with Indium 111-labeled platelets was studied in 18 rabbits. An aortic lesion was made with a balloon catheter in each animal immediately after injection of autologously labeled platelets. Three nonlesioned rabbits with /sup 111/In-labeled platelets served as controls. An additional control study was performed in 12 lesioned rabbits in which nine were injected with /sup 111/In-labeled plasma protein and three with /sup 111/In-labeled red blood cells. A postmortem scanning electron microscope study of the aortae was made to determine the degree of injury to the intima and the amount of platelet deposition on the damaged arterial wall. The radionuclide scans and scanning electron micrographs were then compared. Lesions were seen in ten of 18 animals with labeled platelets that had extensive regions of denuded endothelium covered by a contiguous layer of platelets. Lesions consisting of patchy deendothelialization and platelet deposition could not be visualized on the scans. Red blood cells and fibrin were not conspicuous on micrographs of the lesions. No lesions were visualized in animals receiving /sup 111/In-labeled plasma protein or red blood cells before arterial injury, despite platelet deposition in the lesions.
Research Organization:
Departments of Neurology, Surgery, Radiology, Pathology, and Medicine, Massachusetts General Hospital, Boston
OSTI ID:
6582027
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 145:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AORTA
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DEPOSITION
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
ERYTHROCYTES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MICROSCOPY
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCANNING ELECTRON MICROSCOPY
VASCULAR DISEASES
VERTEBRATES