Computed tomography of the spleen and liver in sickle cell disease

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.143.2.245· OSTI ID:6581580

Magid, D; Fishman, E K; Siegelman, S S

The spleen was assessed in 10 patients with sickle cell disease studied with computed tomography (CT) for abdominal pain and/or unexplained fever. Patients with homozygous sickle cell anemia were found to have small, densely calcified spleens with occasional low-density infarcts. Five of six had hepatomegaly, and there was one case each of hepatic abscess, infarcts, and hemochromatosis. All patients with heterozygous sickle cell disease were found to have splenomegaly, with a variety of findings including acute hemorrhage, acute and chronic infarcts, rupture, and possible sequestration. It was concluded that CT is useful for evaluating the status of the spleen and liver in symptomatic patients with sickle cell disease.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 6581580
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 143:2; ISSN AAJRD
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
ANEMIAS
BODY
CARDIOVASCULAR DISEASES
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HEMIC DISEASES
HEMORRHAGE
ISCHEMIA
LIVER
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
SICKLE CELL ANEMIA
SPLEEN
SYMPTOMS
TOMOGRAPHY
VASCULAR DISEASES