The unit operations approach applied to the synthesis of (1(-/sup 11/)C)2-deoxy-D-glucose for routine clinical applications
An approach to the design of remote semiautomated chemical processing systems has been developed and tested in more than 750 production runs. This design stresses the idea of unit operations, which allows maximum flexibility while maintaining the highest possible standards regarding safety, reliability, efficiency, and practicality. Application of this approach has resulted in the development of a simple and reliable remote semiautomated synthesis system for the routine production of (1(-/sup 11/)C)2-deoxy-D-glucose. Use of this system results in the preparation of a sterile, pyrogen-free product suitable for human injection after a synthesis time of 50 min, with radiochemical purity of greater than 98% and yields (25-30%) permitting quantitative measurements using positron computed tomography.
- Research Organization:
- University of California, Los Angeles, California
- OSTI ID:
- 6581304
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:8
- Country of Publication:
- United States
- Language:
- English
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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CARBON 11
DIAGNOSTIC USES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
AUTOMATION
CHEMICAL REACTION YIELD
DESIGN
GLUCOSE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARBON ISOTOPES
DRUGS
EVEN-ODD NUCLEI
HEXOSES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SACCHARIDES
SYNTHESIS
USES
YIELDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials