Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: a Southwest Oncology Group study
Journal Article
·
· J. Surg. Oncol.; (United States)
- Univ of Texas, San Antonio
Forty-three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full-dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long-term survival duration was not greater than was that for historical controls.
- OSTI ID:
- 6581142
- Journal Information:
- J. Surg. Oncol.; (United States), Vol. 20:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BLEOMYCIN
BIOLOGICAL EFFECTS
CARCINOMAS
CHEMOTHERAPY
RADIOTHERAPY
HEAD
FRACTIONATED IRRADIATION
HYDROXYUREA
NECK
BIOLOGICAL RADIATION EFFECTS
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
PATIENTS
SIDE EFFECTS
SURVIVAL CURVES
AMIDES
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COBALT ISOTOPES
DISEASES
DRUGS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine
BLEOMYCIN
BIOLOGICAL EFFECTS
CARCINOMAS
CHEMOTHERAPY
RADIOTHERAPY
HEAD
FRACTIONATED IRRADIATION
HYDROXYUREA
NECK
BIOLOGICAL RADIATION EFFECTS
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
PATIENTS
SIDE EFFECTS
SURVIVAL CURVES
AMIDES
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COBALT ISOTOPES
DISEASES
DRUGS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine