Termination of acquired and natural immunological tolerance with specific complexes. [Rabbits]

Journal Article · Wed Jan 01 04:00:00 EST 1975 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.142.2.312· OSTI ID:6579234

Habicht, G S; Chiller, J M; Weigle, W O

The termination of an induced unresponsive state can be achieved by immunizing tolerant animals with antigens which cross-react with the tolerated antigen. Data suggest that at 3 months of age, rabbits made tolerant at birth by the injection of large amounts of bovine serum albumin (BSA) possess a normal anti-BSA antibody-forming potential. A cellular interpretation for this phenomenon can be formulated whereby tolerance to BSA at the time of testing is maintained by the functional absence of the BSA-specific carrier recognition mechanism (T cells) in spite of the presence of B cells capable of responding to the antigen. Tolerance could, therefore, be terminated at a time when unresponsiveness to BSA is restricted to specific T cells by using a complex composed of the tolerogen (BSA) conjugated to a carrier molecule. The results demonstrate that such complexes can terminate tolerance.

• Research Organization: Scripps Clinic and Research Foundation, La Jolla, CA
• OSTI ID: 6579234
• Journal Information: J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 142; ISSN JEMEA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
CATTLE
COMPLEXES
DOMESTIC ANIMALS
IMMUNITY
MAMMALS
MAN
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RABBITS
RUMINANTS
SIDE EFFECTS
TOLERANCE
VERTEBRATES