Effects of 2. 45-GHz microwave and 100-MHz radiofrequency radiation on liposome permeability at the phase transition temperature
Large unilamellar dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylglycerol (DPPG) liposomes loaded with an aqueous chemotherapeutic drug, cytosine arabinofuranoside (ARA-C), were exposed for 30 min to 60 W/kg continuous-wave (CW) 100-MHz or 2.45-GHz radiation in vitro at temperatures between 37 degrees C and 43 degrees C. Liposomes were exposed in HEPES buffer or in HEPES buffer supplemented with 44% by volume fetal calf serum (FCS). Characteristic phase transition responses were detected in the range of 39 degrees C to 40 degrees C with the presence of FCS, increasing maximum % release of /sup 3/H-ARA-C by 20% relative to HEPES suspension. Neither frequency of electromagnetic radiation had any detectable effect on liposome permeability or the location of the phase transition in the presence or absence of FCS.
- Research Organization:
- Virginia Commonwealth Univ., Richmond (USA)
- OSTI ID:
- 6578308
- Journal Information:
- Bioelectromagnetics (N.Y.); (United States), Vol. 9:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
LIPOSOMES
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BIOLOGICAL EFFECTS
RADIOWAVE RADIATION
IN VITRO
PHOSPHOLIPIDS
THERMODYNAMICS
TRACER TECHNIQUES
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