Physical analysis of the COR region: a cluster of six genes in Saccharomyces cerevisiae
Journal Article
·
· Mol. Cell. Biol.; (United States)
Six genes, CYC1, UTR1, UTR3, OSM1, tRNAGly, and RAD7, have been localized within an 8-kilobase region on chromosome X of the yeast Saccharomyces cerevisiae. The physical structures and the transcripts of these genes were identified by analyzing a normal strain and six deletion mutants by genomic blotting, transcriptional analysis, and gene disruption procedures. The well-studied CYC1 gene encodes iso-1-cytochrome c; the tRNAGly gene encodes a tRNA; deletion of OSM1 and RAD7 causes sensitivity to hypertonic medium and UV irradiation, respectively. There were no observable phenotypes in strains having deletions of the UTR1, UTR3, and tRNAGly gene. The high density of transcripts, with little or almost no intragenic regions, indicates that the chromosomal organization of S. cerevisiae resembles the chromosomal organization of procaryotes rather than higher eucaryotes.
- Research Organization:
- Univ. of Hawaii, Honolulu
- OSTI ID:
- 6576903
- Journal Information:
- Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 2; ISSN MCEBD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. [Saccharomyces cerevisiae, uv radiation]
Deletions, duplications and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Studies on transposable elements in yeast. II. Deletions, duplications, and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Journal Article
·
Tue Aug 01 00:00:00 EDT 1978
· Genetics; (United States)
·
OSTI ID:6952206
Deletions, duplications and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Conference
·
Mon Dec 31 23:00:00 EST 1979
·
OSTI ID:6774099
Studies on transposable elements in yeast. II. Deletions, duplications, and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· Cold Spring Harbor Symp. Quant. Biol.; (United States)
·
OSTI ID:5580483
Related Subjects
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMOSOMES
DNA REPAIR
FUNGI
GENES
GENETIC MAPPING
GENOTYPE
HETEROCHROMOSOMES
MAPPING
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHENOTYPE
PLANTS
RECOVERY
REPAIR
RNA
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
TRANSCRIPTION
TRANSFER RNA
X CHROMOSOME
YEASTS
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMOSOMES
DNA REPAIR
FUNGI
GENES
GENETIC MAPPING
GENOTYPE
HETEROCHROMOSOMES
MAPPING
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHENOTYPE
PLANTS
RECOVERY
REPAIR
RNA
SACCHAROMYCES
SACCHAROMYCES CEREVISIAE
TRANSCRIPTION
TRANSFER RNA
X CHROMOSOME
YEASTS