CA19-9: A promising tumor marker for pancreatic carcinoma
In order to evaluate CA19-9 as a tumor marker for pancreatic carcinoma (PC), serum levels of CA19-9 were compared with those of CEA and elastase-1 in 56 patients, consisted of 43 cases with histologically proven adenocarcinomas and 13 cases with chronic pancreatitis. Serum levels were determined by using RIA kit obtained from CIS, France (CA19-9 and CEA) and Abbot (elastase-1). CA19-9 gave the highest accuracy among tumor markers the authors have studied and serum levels were markedly elevated over 100U/ml in 30 (70%) cases with PC, whereas none in chronic pancreatitis. CA19-9 values were closely related to the tumor size and the presence or absence of metastsis on CT findings. Small tumors of less than 3cm in diameter, although the site of tumor was limited to the head of the pancreas, showed positive results in 2 out of 5 cases. Furthermore, CA19-9 was at a level of less than 22U/ml in 98 normal controls and was found to be elevated in only 4 (3%) out of 124 patients with benign diseases, including liver diseases, gastric ulcer, cholelithiasis, and so on. These results indicate that CA19-9 is much better in diagnosis and management of PC than is CEA.
- Research Organization:
- Dept. of Nuclear Medicine and Surgery, Faculty of Medicine, Kyoto Univ., Kyoto
- OSTI ID:
- 6575498
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANTIGENS
BIOLOGICAL INDICATORS
BIOLOGICAL MARKERS
BLOOD CHEMISTRY
BODY
CARCINOMAS
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
EVALUATION
GLANDS
HISTOLOGY
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
METABOLISM
NEOPLASMS
ORGANS
PANCREAS
PATIENTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
TRACER TECHNIQUES