Dibromochloropropane (DBCP): an 8-year reevaluation of testicular function and reproductive performance
The current study summarizes an 8-year reassessment of testicular function and reproductive performance in 15 workers with dibromochloropropane (DBCP)-induced azoospermia and oligozoospermia. Recovery of spermatogenesis was observed in four oligozoospermic and three azoospermic men whose plasma follicle-stimulating hormone (FSH) concentration was normal during the whole period. A marked increase in FSH and luteinizing hormone concentrations above the upper limit of normal was found in the azoospermic workers who did not recover. No significant changes in FSH concentrations were detected in both recovered and nonrecovered oligozoospermic men. Testosterone levels of all patients were normal at all times. Paternal exposure to DBCP was not associated with increased risk of fetal malformations or spontaneous abortion.
- Research Organization:
- Soroka Univ. Hospital, Beer-Sheba, Israel
- OSTI ID:
- 6570750
- Journal Information:
- Fert. Steril.; (United States), Journal Name: Fert. Steril.; (United States) Vol. 2; ISSN FESTA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
ANDROGENS
ANDROSTANES
BIOLOGICAL FUNCTIONS
BODY
CHEMICAL INDUSTRY
FSH
FUNCTIONS
GAMETOGENESIS
GONADOTROPINS
GONADS
HAZARDS
HEALTH HAZARDS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
INDUSTRY
KETONES
LH
MALE GENITALS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PERSONNEL
PITUITARY HORMONES
PROPANE
REPRODUCTION
RISK ASSESSMENT
SPERMATOGENESIS
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
TOXICITY