Biostimulation of wound healing in vivo by a helium-neon laser
Clinical observations have suggested that low-energy lasers might stimulate wound healing. To understand the mechanism of the biostimulation, we previously examined the effects of low-energy lasers on collagen production by human skin fibroblasts and reported an increase of collagen synthesis in vitro. To examine the effects of low-energy lasers in vivo, hairless mice were experimentally wounded, sutured, and subjected to laser irradiation by a helium-neon laser with a power output of 1.56 mW and an energy fluence of 1.22 Joules/cm2. Experimental wounds were subjected to laser treatment every other day for 2 months; control wounds remained untreated. Specimens from the wounds were then examined for histological findings, tensile strength, and total collagen content. Results demonstrated a considerable improvement in the tensile strength of the laser-irradiated wounds at 1 and 2 weeks. Furthermore, the total collagen content was significantly increased at 2 months when compared with control wounds. These results suggest a beneficial effect of the helium-neon laser on wound healing in vivo.
- Research Organization:
- Univ. of California, Los Angeles
- OSTI ID:
- 6570041
- Journal Information:
- Ann. Plast. Surg.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COLLAGEN
BIOSYNTHESIS
LASER RADIATION
BIOLOGICAL EFFECTS
WOUNDS
HEALING
BIOLOGICAL MODELS
HELIUM-NEON LASERS
IN VIVO
MICE
ANIMALS
BIOLOGICAL RECOVERY
ELECTROMAGNETIC RADIATION
GAS LASERS
INJURIES
LASERS
MAMMALS
ORGANIC COMPOUNDS
PROTEINS
RADIATIONS
RECOVERY
RODENTS
SCLEROPROTEINS
SYNTHESIS
VERTEBRATES
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