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Biostimulation of wound healing in vivo by a helium-neon laser

Journal Article · · Ann. Plast. Surg.; (United States)
; ; ; ; ;
Clinical observations have suggested that low-energy lasers might stimulate wound healing. To understand the mechanism of the biostimulation, we previously examined the effects of low-energy lasers on collagen production by human skin fibroblasts and reported an increase of collagen synthesis in vitro. To examine the effects of low-energy lasers in vivo, hairless mice were experimentally wounded, sutured, and subjected to laser irradiation by a helium-neon laser with a power output of 1.56 mW and an energy fluence of 1.22 Joules/cm2. Experimental wounds were subjected to laser treatment every other day for 2 months; control wounds remained untreated. Specimens from the wounds were then examined for histological findings, tensile strength, and total collagen content. Results demonstrated a considerable improvement in the tensile strength of the laser-irradiated wounds at 1 and 2 weeks. Furthermore, the total collagen content was significantly increased at 2 months when compared with control wounds. These results suggest a beneficial effect of the helium-neon laser on wound healing in vivo.
Research Organization:
Univ. of California, Los Angeles
OSTI ID:
6570041
Journal Information:
Ann. Plast. Surg.; (United States), Journal Name: Ann. Plast. Surg.; (United States) Vol. 1; ISSN APCSD
Country of Publication:
United States
Language:
English

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Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RECOVERY
BIOSYNTHESIS
COLLAGEN
ELECTROMAGNETIC RADIATION
GAS LASERS
HEALING
HELIUM-NEON LASERS
IN VIVO
INJURIES
LASER RADIATION
LASERS
MAMMALS
MICE
ORGANIC COMPOUNDS
PROTEINS
RADIATIONS
RECOVERY
RODENTS
SCLEROPROTEINS
SYNTHESIS
VERTEBRATES
WOUNDS