Effect of purine nucleosides and nucleotides on the in vivo radiation response of normal tissue in the rat
WAG/Rij rats were exposed to single doses of radiation following intraperitoneal injection of inosine, pyruvate and inorganic phosphate (IPP). When skin reactions and structural damage were scored in the hind legs of irradiated rats, IPP was observed to decrease radiation sensitivity. Radioprotection was also observed in rats that were pretreated with ionosine alone and with the purine nucleosides adenosine and guanosine. The purine nucleotides 5'-inosine monophosphate (IMP), 5'-adenosine monophosphate (AMP), 5'-guanosine monophosphate (GMP) and cyclic adenosine 3',5'-monophosphate (cyclic AMP) were also protective. The purine bases hypoxanthine, adenine and guanine were not protective. A decline in blood pressure was observed following administration of either IPP or inosine alone but not following AMP or cyclic AMP. The mechanism(s) whereby the purine nucleosides and nucleotides result in radioprotection are currently being investigated.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 6569822
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:3; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENINES
ADENOSINE
AMINES
AMP
ANIMALS
ANTIMETABOLITES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD PRESSURE
BODY
BODY AREAS
CARBOXYLIC ACIDS
DRUGS
ELECTROMAGNETIC RADIATION
GUANINE
GUANOSINE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
HYPOXANTHINE
INOSINE
IONIZING RADIATIONS
KETO ACIDS
LEGS
LIMBS
MAMMALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
PURINES
PYRUVIC ACID
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RIBOSIDES
RODENTS
SKIN
VERTEBRATES
X RADIATION