Protection of normal tissue against late radiation injury by WR-2721. [/sup 60/Co; rats]

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575574· OSTI ID:6567145

Utley, J F ^[1]; Quinn, C A; White, F C; Seaver, N A; Bloor, C M

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1. Univ. of California, San Diego

The ability of WR-2721 to protect against late radiation damage has been studied in skin, muscle, and vascular tissues of rats. Animals treated with and without WR-2721 received irradiation to the left hind limb; representative groups were killed at intervals ranging from 72 h to 6 months. Comparison of all drug-treated and non-drug-treated animals showed significant protection (P = less than or equal to 0.05). The time pattern of injury in non-drug-treated rats was biphasic, with significant damage occurring at 72 h and 1 week, returning to normal between 1 and 3 months, but showing significant late damage at 6 months (P = less than or equal to 0.001). Again, this injury pattern did not appear in WR-2721-treated rats. Thus the ability of WR-2721 to protect against acute and chronic radiation injury in vessels, skin, and muscle indicates that an increased therapeutic gain can be expected when this drug is used in clinical radiation therapy.

• OSTI ID: 6567145
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ATROPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
EVALUATION
EVEN-ODD NUCLEI
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RODENTS
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
SKIN
VERTEBRATES
YEARS LIVING RADIOISOTOPES