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Treatment of antigen-induced arthritis in rabbits with dysprosium-165-ferric hydroxide macroaggregates

Journal Article · · J. Orthop. Res.; (United States)
; ; ;
Dysprosium-165-ferric hydroxide macroaggregates (/sup 165/Dy-FHMA) was used as an agent of radiation synovectomy in an antigen-induced arthritis model in New Zealand white rabbits. Animals were killed up to 6 months after treatment. /sup 165/Dy-FHMA was found to have a potent but temporary antiinflammatory effect on synovium for up to 3 months after treatment. Treated knees also showed significant preservation of articular cartilage architecture and proteoglycan content compared with untreated controls, but only during the first 3 months after treatment. In animals killed 3 and 6 months after treatment there were only minimal differences between the treated and untreated knees, indicating that the antiinflammatory effects on synovial tissue and articular cartilage preservation were not sustained.
Research Organization:
Center for Arthritis Management, New York, NY (USA)
OSTI ID:
6566592
Journal Information:
J. Orthop. Res.; (United States), Journal Name: J. Orthop. Res.; (United States) Vol. 7:1; ISSN JORED
Country of Publication:
United States
Language:
English

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Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BODY
CARBOHYDRATES
CARTILAGE
CONNECTIVE TISSUE
DISEASES
DYSPROSIUM 165
DYSPROSIUM ISOTOPES
EVEN-ODD NUCLEI
FIBROSIS
GLUCOPROTEINS
GLYCOPROTEINS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANIC COMPOUNDS
OVALBUMIN
PARTICLE SIZE
PATHOLOGICAL CHANGES
PROTEINS
RABBITS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RHEUMATIC DISEASES
SACCHARIDES
SIZE
SKELETAL DISEASES
THERAPY
TISSUES
VERTEBRATES