Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-oat cell carcinoma of the lung - report by the Radiation Therapy Oncology group

Journal Article · Wed Sep 15 04:00:00 EDT 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19820915)50:6<1091::AID-CNCR2820500612>3.0.CO;2-0· OSTI ID:6566498

Perez, C A ^[1]; Stanley, K; Grundy, G

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1. Washington Univ. School of Medicine, St. Louis, MO

An analysis of intrathoracic tumor control was carried out in 378 patients with histologically proven unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy, randomized to one of four treatment regimens: 4000 rad split course (2000 rad in five fractions in one week, two weeks rest and additional 2000 rad in five fractions in one week) or 4000, 5000 or 6000 rad continuous courses, five fractions per week. Between 85 and 101 patients are analyzed in each treatment group. The complete plus partial response was 46-51% in the 4000 rad groups in contrast to 61-66% in the 5000 to 6000 rad groups (P = 0.008). The overall two year survival rate was 10-11% for the patients treated with 4000 rad split or continuous course, and 19% in the patients treated with 5000 to 6000 rad. The complete response in patients with tumors 3 cm or less in diameter was 16% when treated with 4000 rad in contrast to 20-31% in those treated with 5000-6000 rad. In the patients with lesions from 4 to 6 cm in diameter, complete and partial tumor regression was 48% in the 4000 rad group, 67% with 5000 rad, and 71% with 6000 rad. Strict quality assurance criteria in radiotherapy are necessary to achieve optimal treatment results and a careful program to evaluate techniques of irradiation and protocol compliance should be maintained in cooperative group studies in order to enhance the validity of clinical trials. (JMT)

• OSTI ID: 6566498
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:6; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EVALUATION
FRACTIONATED IRRADIATION
IRRADIATION
LUNGS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SURVIVAL TIME
THERAPY