Neurofibrosarcoma at irradiation site in a patient with neurofibromatosis and Wilms' tumor
Journal Article
·
· Ca - Cancer J. Clin.; (United States)
A female patient with neurofibromatosis had nephrectomy performed because of Wilms' tumor at the age of four and a half. She received radiation therapy and chemotherapy (actinomycin D) after surgery. She had subsequent local recurrence and lung metastasis, which were surgically excised and successfully treated with additional radiation therapy and chemotherapy (vincristine and actinomycin D). However, neurofibrosarcoma at the irradiation site developed seven years after radiation therapy. She died 22 months later because of recurrence and metastasis of neurofibrosarcoma. Radiation therapy's association with malignant transformation of neurofibroma is discussed.
- Research Organization:
- Department of Pediatrics-Adolescent Medicine, St. Louis University School of Medicine, Missouri
- OSTI ID:
- 6565732
- Journal Information:
- Ca - Cancer J. Clin.; (United States), Journal Name: Ca - Cancer J. Clin.; (United States) Vol. 31:6; ISSN CAMCA
- Country of Publication:
- United States
- Language:
- English
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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
DISEASES
FIBROSARCOMAS
KIDNEYS
MEDICINE
METASTASES
NEOPLASMS
NEPHRECTOMY
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SURGERY
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550900 -- Pathology
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMOTHERAPY
DISEASES
FIBROSARCOMAS
KIDNEYS
MEDICINE
METASTASES
NEOPLASMS
NEPHRECTOMY
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SURGERY
THERAPY
TUMOR CELLS