Selective vascular coagulation of rabbit colon using a flashlamp-excited dye laser operating at 577 nanometers

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Gastroenterology; (United States)

OSTI ID:6556577

Nishioka, N S; Tan, O T; Bronstein, B R; Farinelli, W A; Richter, J M; Parrish, J A; Anderson, R R

Previous studies have demonstrated that brief pulses of selectively absorbed optical radiation can be used to confine thermal injury to pigmented targets within tissues. We performed studies in rabbits to assess the usefulness of this technique for selectively coagulating the colonic vasculature. By measuring the optical absorbance of rabbit colon with a spectrophotometer, it was determined that hemoglobin exhibits strong absorption relative to the rabbit colon at a wavelength of 577 nm. Because light must be absorbed to affect tissue, it was hypothesized that laser pulses of this wavelength would selectively damage blood vessels. This hypothesis was tested by examining the effect of 300-microseconds-long 577-nm laser pulses on rabbit colon in vivo. For delivered radiant exposures between 4 and 8 J/cm2, selective coagulation of the colonic vasculature could be produced without damage to the surrounding colon. At greater radiant exposures, vessel hemorrhage was occasionally noted but no transmural thermal injury was produced with delivered radiant exposures as high as 22 J/cm2. This technique may form the basis of a safe and simple treatment of vascular lesions of the colon such as angiodysplasia.

• Research Organization: Massachusetts General Hospital, Boston (USA)
• OSTI ID: 6556577
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 95:5; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD VESSELS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
DYE LASERS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
GASTROINTESTINAL TRACT
GLOBIN
HEMOGLOBIN
HEMORRHAGE
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTESTINES
LARGE INTESTINE
LASER RADIATION
LASERS
LIQUID LASERS
MAMMALS
MATERIALS
MEASURING INSTRUMENTS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PIGMENTS
PORPHYRINS
PROTEINS
RABBITS
RADIATIONS
SPECTROPHOTOMETERS
SYMPTOMS
VERTEBRATES