Long-term persistence of human anti-murine antibody responses following radioimmunodetection and radioimmunotherapy of cutaneous T-cell lymphoma patients using /sup 131/I-T101

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Exp. Hematol.; (United States)

OSTI ID:6555132

Goldman-Leikin, R E; Kaplan, E H; Zimmer, A M; Kazikiewicz, J; Manzel, L J; Rosen, S T

Five cutaneous T-cell lymphoma (CTCL) patients have been imaged and treated with radiolabeled murine monoclonal antibody /sup 131/I-T101 in our laboratory. All patients developed human anti-murine antibody responses (HAMA) 14 days after the primary antibody infusion. HAMA responses could still be detected more than 22 months after T101 treatment. A substantial proportion of HAMA was crossreactive with any IgG2a antibody tested, although there did exist a specific anti-idiotypic component to HAMA. HAMA were of both IgM and IgG isotype. We also analyzed the effects of plasmapheresis on the specific HAMA isotypes in three patients who were retreated at the time of disease progression.

• Research Organization: Northwestern Univ., Chicago, IL (USA)
• OSTI ID: 6555132
• Journal Information: Exp. Hematol.; (United States), Journal Name: Exp. Hematol.; (United States) Vol. 16:10; ISSN EXHMA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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