Diffusional anisotropy of the human brain assessed with diffusion-weighted MR: Relation with normal brain development and aging

Journal Article · Tue Feb 01 04:00:00 EST 1994 · AJNR. American Journal of Neuroradiology; (United States)

OSTI ID:6553143

Nomura, Toshiyuki; Sakuma, Hajime; Takeda, Kan; Tagami, Tomoyasu; Okuda, Yasuyuki; Nakagawa, Tsuyoshi ^[1]

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1. Mie Univ. School of Medicine (Japan)

To analyze diffusional anisotropy in frontal and occipital white matter of human brain quantitatively as a function of age by using diffusion-weighted MR imaging. Ten neonates (<1 month), 13 infants (1-10 months), 9 children (1-11 years), and 16 adults (20-79 years) were examined. After taking axial spin-echo images of the brain, diffusion-sensitive gradients were added parallel or perpendicular to the orientation of nerve fibers. The apparent diffusion coefficient parallel to the nerve fibers (0) and that perpendicular to the fibers (90) were computed. The anisotropic ratio (90/0) was calculated as a function of age. Anisotropic ratios of frontal white matter were significantly larger in neonates as compared with infants, children, or adults. The ratios showed rapid decrease until 6 months and thereafter were identical in all subjects. In the occipital lobe, the ratios were also greater in neonates, but the differences from other age groups were not so prominent as in the frontal lobe. Comparing anisotropic ratios between frontal and occipital lobes, a significant difference was observed only in neonates. Diffusion-weighted images demonstrated that the myelination process starts earlier in the occipital lobe than in the frontal lobe. The changes of diffusional anisotropy in white matter are completed within 6 months after birth. Diffusion-weighted imaging provides earlier detection of brain myelination compared with the conventional T1- and T2-weighted images. 18 refs., 6 figs., 1 tab.

• OSTI ID: 6553143
• Journal Information: AJNR. American Journal of Neuroradiology; (United States), Journal Name: AJNR. American Journal of Neuroradiology; (United States) Vol. 15:2; ISSN 0195-6108; ISSN AAJNDL
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
AGE GROUPS
ANISOTROPY
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIFFUSION
FEASIBILITY STUDIES
GROWTH
MAGNETIC RESONANCE
MEMBRANES
MYELIN
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
ORGANS
RESONANCE
SPIN ECHO
USES