Relationship of five anthropometric measurements at age 18 to radiation dose among atomic bomb survivors exposed in utero

Journal Article · Fri Apr 01 04:00:00 EST 1994 · Radiation Research; (United States)

DOI:https://doi.org/10.2307/3578855· OSTI ID:6551260

Nakashima, Eiji ^[1]

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1. Radiation Effects Research Foundation, Minami-ku (Japan)

Five body measurements-standing height, body weight, sitting height, chest circumference and intercristal diameter-of 18-year-old atomic bomb survivors exposed in utero in Hiroshima and Nagasaki were analyzed in relation to DS86 uterine dose. Age in utero was divided into four periods: 0-7, 8-15, 16-25 and [>=]26 weeks. This categorization is based upon the study of radiation-induced brain damage. The linear regression analyses for these five variables showed significant decreases with increasing dose. The regression coefficients were -2.65 cm/Gy for standing height, -2.46 kg/Gy for body weight, -0.92 cm/Gy for sitting height, -1.37 cm/Gy for chest circumference and -0.32 cm/Gy for intercristal diameter. The multivariate test statistic for the overall dose effect on five body measurements was significant, but the interaction between dose and gestational period was not significant. Principal-component analysis was applied to the five variables. For the first-component scores, the dose effect was significant, but the interaction between dose and gestational period was not significant. For the second-component scores, the dose effect was significant specifically at 0.7 weeks. The radiation dose effect on the second principal component found at 0-7 weeks of gestation suggests that malformation occur in this period. 17 refs., 2 figs., 4 tabs.

• OSTI ID: 6551260
• Journal Information: Radiation Research; (United States), Journal Name: Radiation Research; (United States) Vol. 138:1; ISSN 0033-7587; ISSN RAREAE
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ADULTS
AGE GROUPS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DEVELOPED COUNTRIES
DIMENSIONS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EPIDEMIOLOGY
HEIGHT
HIROSHIMA
HUMAN POPULATIONS
IRRADIATION
JAPAN
NAGASAKI
POPULATIONS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION DOSES
RADIATION EFFECTS
WEIGHT